Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells

Abstract The onset of erythropoiesis is under strict developmental control, with direct and indirect inputs influencing its derivation from the hematopoietic M.I.C. stem cell.A major regulator of this transition is KLF1/EKLF, a zinc finger transcription factor that plays a global role in all aspects of erythropoiesis.Here, we have identified a shor

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H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

Histone posttranslational modifications play a fundamental role in orchestrating gene expression.In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels

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Study on heat transfer enhancing performance of spiral groove tube in phase change heat storage for solar energy

Based on the energy storage problems for solar energy utilization and the advantages of spiral groove tube heat exchanger, spiral groove tubes are used in the solar energy phase change heat storage, with numerical simulation of the thermal storage process of heat reservoir.Firstly, the simulation method and the reliability of the used model are ver

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